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Finally, decreased activation of the farnesoid X receptor (FXR) in the distal small intestine by bile acids may also contribute to impaired integrity of the intestinal barrier (127)

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Vavricka SR, Rogler G, Gantenbein C, Spoerri M, Prinz Vavricka M, Navarini AA, et al

The peptide sits on the skins surface

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